Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, a key enzyme involved in the synthesis of DNA, RNA, and proteins. By interfering with folate metabolism, Methotrexate disrupts the production of nucleotide precursors, leading to inhibition of cell division and proliferation.
Methotrexate is used as a tool to study cellular processes related to DNA and RNA synthesis. Also, it serves as a model for the development of new drugs. Researchers study its structure and mechanisms to design novel compounds with improved efficacy and reduced side effects. Pharmacogenomics research explores genetic factors influencing individual responses to methotrexate.
WARNING! This product can expose you to Methotrexate, a chemical which is known to the State of California to cause developmental harm. For more information go to www.P65Warnings.ca.gov.