Bafilomycin B1,
1 Milligram
RPI-B52100-0.001

Bafilomycin B1,
1 Milligram
RPI-B52100-0.001

Research or further manufacturing use only, not for food or drug use.

Molecular Weight: 816.0

Chemical Formula: C44H65NO13

Solubility: Methanol, Ethanol, DMF or DMSO

Storage Temperature: -20°C

Bafilomycin B1 is a naturally occurring macrolide antibiotic that is produced by certain strains of Streptomyces bacteria. It is a derivative of bafilomycin, a compound known for its inhibitory effects on the vacuolar-type H+-ATPase (V-ATPase) enzyme.

Similar to other members of the bafilomycin family, Bafilomycin B1 has gained attention in the field of life sciences for its ability to selectively inhibit V-ATPase. This enzyme is responsible for maintaining the acidic pH in various cellular compartments, including lysosomes and endosomes. By inhibiting V-ATPase, it disrupts the acidification process within these compartments. This disruption can have profound effects on various cellular processes and pathways that rely on proper pH regulation, such as protein degradation, autophagy, and vesicular trafficking.

Due to its ability to modulate cellular pH and inhibit V-ATPase, Bafilomycin B1 has been widely used as a research tool to study the role of lysosomes, autophagy, and cellular homeostasis. It has been particularly useful in investigations related to autophagic flux, lysosomal degradation, and the interplay between autophagy and disease processes.