17-AAG
[17(Allyamino)-17-demothoxygeldanamycin],
1 Milligrams
RPI-A20045-0.001

17-AAG
[17(Allyamino)-17-demothoxygeldanamycin],
1 Milligrams
RPI-A20045-0.001

Research or further manufacturing use only, not for food or drug use.

Common Name: 17(Allylamino)-17-demethoxygeldanamycin

CAS Number: 75747-14-7

Molecular Weight: 585.7

Chemical Formula: C31H43N3O8

Solubility: DMSO, Methanol

Storage Temperature: -20°C

17-AAG (17-Allylamino-17-demethoxygeldanamycin) is a synthetic derivative of geldanamycin. Like geldanamycin, 17-AAG is recognized for its role as an inhibitor of heat shock protein 90 (Hsp90), a molecular chaperone involved in protein folding and stabilization.

It is often used as a tool to study Hsp90-dependent processes. By inhibiting Hsp90, 17-AAG impacts the stability and function of various client proteins, many of which are involved in critical cellular processes, including signal transduction and cell cycle regulation. Similar to geldanamycin, 17-AAG is particularly relevant in cancer research, as Hsp90 is often crucial for the stability of oncoproteins.

Researchers use 17-AAG to explore the molecular mechanisms of Hsp90 inhibition, with potential applications in understanding cancer biology and developing therapeutic strategies.